False-negative interferon-γ release assay results in active tuberculosis: a TBNET study.
نویسندگان
چکیده
2014; 43: 1410–1420. 9 Esposito S, D’Ambrosio L, Tadolini M, et al. ERS/WHO Tuberculosis Consilium assistance with extensively drug-resistant tuberculosis management in a child: case study of compassionate delamanid use. Eur Respir J 2014; 44: 811–815. 10 Codecasa LR, Ciconali G, Mazzola E. Managing an XDR-TB outbreak: the public health face of the medal. Eur Respir J 2015; 45: 292–294. 11 Smit PW, Haanperä M, Rantala P, et al. Molecular epidemiology of tuberculosis in Finland, 2008–2011. PLoS One 2013; 8: e85027 12 Rangaka MX, Wilkinson KA, Glynn JR, et al. Predictive value of interferon-γ release assays for incident active tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2012; 12: 45–55. 13 Hinks TS, Varsani N, Godsiff DT, et al. High background rates of positive tuberculosis-specific interferon-γ release assays in a low prevalence region of UK: a surveillance study. BMC Infect Dis 2012; 12: 339. 14 Bradshaw L, Davies E, Devine M, et al. The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident. PLoS One 2011; 6: e20770. 15 Fox GJ, Barry SE, Britton WJ, et al. Contact investigation for tuberculosis: a systematic review and meta-analysis. Eur Respir J 2013; 41: 140–156.
منابع مشابه
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Interferon-γ release assays (IGRAs) are the preferred diagnostic test for tuberculosis (TB) infection in at-risk populations in developed countries. However, IGRAs have high false-negative rates in patients with TB disease. Population-based studies assessing the factors associated with negative IGRA results in TB patients have not been performed. Using statewide TB surveillance data of culture-...
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Background: Interferon gamma (IFN-γ), a cytokine produced by a variety of cells is involved in the immune response against M. tuberculosis. It activates the production of other cytokines and molecules that kill mycobacterium. IFN-γ also has diagnostic role in identification of active and latent tuberculosis. Objective: To determine the level of IFN-γ in the blood of TB patients. Methods: Ninety...
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BACKGROUND False negative and indeterminate Interferon Gamma Release Assay (IGRA) results are a well documented problem. Cigarette smoking is known to increase the risk of tuberculosis (TB) and to impair Interferon-gamma (IFN-γ) responses to antigenic challenge, but the impact of smoking on IGRA performance is not known. The aim of this study was to evaluate the effect of smoking on IGRA perfor...
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عنوان ژورنال:
- The European respiratory journal
دوره 45 1 شماره
صفحات -
تاریخ انتشار 2015